Welsh AL. Image  Elizabeth Hammond, MD, University of Utah. One study showed that a 4% niacinamide gel used twice daily for two months significantly reduced acne lesions.7 Other trials have demonstrated that a 20% azelaic acid cream worked as well as benzoyl peroxide, oral tetracycline and retinoic acid.8 9 Although these topical formulas are natural substances, they are available only by prescription. That is 900mg a day. Could there really be a magic pill for acne? They were given 10 grams of pantothenic acid a day in four divided doses. Left Image:  Note Sebum (pink) in this diagram of hair follicle with sebaceous glands and sebum (pink). Let’s fix that now. These drugs have nothing in common except they are metabolized by the acetylation pathway, a connection to Acetyl CoA. The information on this site does not constitute legal, medical  or technical advice. She appeared under weight and chronically ill, and had absent menses for the last 7 years. The goal is to get up to 10 grams, or as close as possible without experiencing any negative side effects. M.D. • Zinc methionine 50 mg However, with the development of better absorbed forms of zinc, many doctors now recommend 30 mg two or three times per day initially, and lower amounts after the first 12 weeks. So for those with short attention span here are the keypoints: 1. The first manifestations of Deficiency States are in the skin, joint and connective tissue with various lesions. Nutritional Supplements In The Treatment Of Acne. CoA is essential for the generation of energy from fat, carbohydrate, and protein. The recommended dosage for adults is 5 mg per day. Pantethine: A Review of their Biochemistry and Therapeutic Applications Initial testing showed low salivary cortisol,  and low serum levels for the other hormones, DHEA, estradiol, progesteron and testosterone. John D. McCarthy, Norfolk, Virginia . A Stone that Kills two Birds: How Pantothenic Acid Unveils the Mysteries of Acne Vulgaris and Obesity… LH Leung - Journal of Orthomolecular Medicine, 1997 - orthomolecular.org. Pantothenic Acid. DHEA for Lupus However, a number of features of Lupus suggest a link with steroid hormone synthesis. Above diagram courtesy of wikipedia showing L-Carnitine transporting fatty acids into the mitochondria where they can be oxidized. While prescription medications may be effective, many of these substances have side effects that limit the duration of use. You should talk with your health care provider for complete information about the risks and benefits of using this product. Michaelsson G, Juhlin L, Ljunghall K. A double blind study on the effect of zinc and oxytetracycline in acne vulgaris. There can be increased facial skin pigmentation in pregnancy itself (without lupus) called Melasma, also known as chloasma or the mask of pregnancy. 3. In 2014 a study was published that reported success treating acne using a high dose of pantothenic acid, also known as Vitamin B5. The vitamin was first isolated in 1931, and its role as an essential component in the growth of yeast cells was demonstrated in 1933. Conclusion. Pantothenic Acid in the Treatment of Obesity Dr. Leung also proposed a mechanism, stating that CoA regulates both hormones and fatty acids, and without sufficient quantities of pantothenic acid, CoA will preferentially produce androgens. Dosage is based on your condition. When dosed above the recommended dietary allowance, pantothenic acid is designated Category C (ie, Risk cannot be ruled out. Natural Solutions with Bio Identical HormonesÂ, Virtually everyone remembers the frustrating experience of acne with small inflamed dots called pimples or blackheads. Then I had only minor breakouts from taking B5 regularly, so I bought some and took B5 and pantethine together for quite some time, and it definitely had more of a beneficial effect. Lupus  preferentially affects females because they have greater demands for hormone production than do males. Co-Enzyme A and Pantothenic Acid for Acne Finally, if you wish for the most benefit, then try and find a health … In high doses, pantothenic acid may inhibit the absorption of biotin produced by the microflora in the large intestine. In an adequate dosage, pantothenic acid is likely safe and well-tolerated, including children and pregnant women. The following information includes only the average doses of this medicine. guys, This article originally appeared in the scientifically prestigious Journal of Orthromolecular Medicine Vol. The US RDA for pantothenic acid in nutritional supplements and foods is age dependent and ranges from 0.2 mg/kg in infants to 5 mg in adults. 300mg for me is equivalent to about 6grams of B5. What are the Acne Treatments? http://www.mitamins.com/library/Concern/Lupus.html. Just read the reviews, and you will see that not all brands of Pantothenic Acid are the same. If you want to try it, try and include a 450mg or 300mg pill and gradually diminish your B5 dosage over time. Pantothenic acid is a vitamin, also known as vitamin B5, used as a dietary supplement when taken in recommended daily allowances (RDAs), and also to treat pantothenic acid deficiency. Med Hypotheses 1995;44:490–2. Jul 16 2007, 12:44 PM There are very few adverse reactions that do take place from taking pantothenic acids. A few studies that looked into acne treatment with pantothenic acid suggested a mega-dose of Vitamin B5 of 2-4 grams a day. Acne tends to be a common issue for lupus patients given DHEA, and this would be expected assuming there is an underlying B5/Acetyl CoA deficiency. Pantothenic acid is safe and effective for individuals with high level of total … The Effect of Pantothenic Acid on Acne Vulgaris Dr Leung's Dosage is Rather Large LUPUS ERYTHEMATOSUS: A COMBINED DEFICIENCY DISEASE LUPUS ERYTHEMATOSUS: A COMBINED DEFICIENCY DISEASE Lit-Hung Leung, M.D. I have had moderate acne for 30 years... had 4 rounds of accutane. She had been to many rheumatologists and specialists over the years with a confirmed diagnosis of lupus. • Barberry root bark xpowder (berberine) 500 mg, Pantethine: I now only wish I had discovered B5 and pantethine earlier in my life like when I was in high school. Compared to accutane (stores in the liver) risks are minor. Before damage could be done to my face I got another bottle of Clear Skin Image. Pantothenic acid, also known as vitamin B5, is commonly supplemented in large doses to reduce oil production and help rid your skin of acne. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Verma KC, Saini AS, Dhamija SK. Coenzyme-ATM "Precursor The Master CoenzymeTM" In some of these cases, in order to get a more immediate response, it may even be necessary to step up the dose to 15-20 grams a day. Accutane works by shrinking the sebaceous glands at the root of the hair follicles. 7450 Griffin Rd Suite 180/190 considered to be related to the supplementation, although it was also noted that 11 patients developed new lesions whilst undergoing therapy. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. Women with premenstrual acne may find benefit with vitamin B6. Another interesting feature of Lupus is that the disease can be caused by 70 various drugs. Nightly: Gentle Retinol Night Serum followed by either Treatment Oil or Rejuvenating Night Oil. Consult with your doctor to get the required amount of Vitamin B5 dosage that is suitable for your body. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. J. ------------------ PANTOTHENIC ACID Side Effects . It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. http://www.ncbi.nlm.nih.gov/pubmed/7476595?dopt=Abstract Vitamin B5 deficiency is extremely rare in people as pantothenic acid is found in nearly … BTW: I am an inorganic chemist and medical researcher. He reported success with this regimen. http://www.vilantae.com/index.php Pantothenic acid is better known as vitamin B-5 1 2 3. If there is a deficiency of Acetyl CoA in the body, oxidation of fatty acids will slow down, and the skin becomes oily resulting in acne. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. As acne lesions tend to subside spontaneously after puberty, some patients do not need a maintenance dose. By critically analyzing clinical facts and laboratory data, a hypothesis is proposed: drug-induced lupus erythematosus (DILE) is linked to a deficiency in Coenzyme A (CoA) that is secondary to a deficiency in pantothenic acid. This information should not be used to decide whether or not to take this product. Vestn Dermatol Venerol. Phone: 954-792-4663 • Vitamin A acetate 5000 IU • Vitamin E succinate 400 IU • Vitamin B-6 50 mg • Pantothenic acid 500 mg • Zinc methionine 50 mg • Selenium (L-selenomethionine) 200 µg • Chromium polynicotinate 200 µg • … Almost immediately after I started, my bowel movements became regular. Also, Addisons Disease,  adrenal failure, or failure to produce sufficient adrenal hormones results in hyper-pigmentation changes in the face and elsewhere. In another study, high amounts of vitamin A were used to treat severe acne in teenagers.5 Girls took up to 300,000 IU per day and boys took up to 500,000 IU per day. After two weeks, existing lesions start to regress while the rate of eruption of new acne lesions begins to slow down. Common sources of pantothenic acid include liver, queen bee jelly, yeast, rice bran, molasses, peanuts, tree nuts, whole grains, mushrooms, eggs, milk, and potatoes. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… Learn more about Pantothenic Acid (Vitamin B5) uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Pantothenic Acid (Vitamin B5) extremely high doses of pantothenic acid derivatives, with the aim to alleviate Symptoms include fatigue, apathy, sleep disturbances, GI symptoms, numbness and paresthesias, muscle cramps, and hypoglycemia.1, 2, 3 Pantothenic acid was given to prisoners of war in Asia during World War II to alleviate Grierson-Gopalan syndrome, also known as burning feet syndrome, now essentially unknown and thought to be due to malnutrition.1, 2. CoA is used at the cellular level for fatty acid oxidation and in many other biochemical reactions in the cell. I myself have used the program and can report that it works quite well. For example, a 12-week study in 41 adults with mild to moderate acne observed a significant reduction in inflamed lesions in those who consumed a pantothenic-acid-based … It also plays an important role in the body’s use of vitamin D in bone formation. Hence, the effect of hormonal factors in this disease entity becomes secondary to that of the availability of pantothenic acid. I first became aware of the use of Vitamin B5 (also called pantothenic acid) as a treatment for acne from an article by Lit-Hung Leung (1997). In cases with moderate severity, the condition is normally in complete control in about eight weeks, with most of the lesions gone and new lesions only to erupt occasionally. For acne reduction, vitamin B5 has to be taken with a dosage of at least 5 grams, and some people take as much as 20 grams… http://www.journals.elsevierhealth.com/periodicals/ymehy/article/PIIS0306987704000945/abstract It may contain copyrighted material the use of which has not always been specifically authorized by the copyright owner. Clinical studies are limited. A person had to get a painful kidney stone removed because of the calcium buildup from megadosing on B5. No new breakouts!! The majority of these events were mild GI complaints.16, Pantothenic acid is considered to be relatively safe. Amazingly, I experienced no side effects for 2 years. Like I said, my skin became much drier. 2. Food Almost all plant- and animal-based foods contain pantothenic acid in varying amounts. Although no significant side effects occurred, the long-term safety of such large amounts taken orally has not been studied. The idea of vitamin b5 for acne solution became popular after the publication of the paper by Dr. Lit-Hung Leung in 1997. My intent is simply to talk about my experience curing acne with Pantothenic Acid, and maybe help you a little bit on your journey towards clearing yours. Dexpanthenol as a pastille and as a spray has been evaluated in small clinical trials for wound healing in postoperative tonsillectomy, endotracheal intubation, and endoscopic sinus surgery.25, 26, 27 Increased hydration due to dexpanthenol may explain the positive effects, or a possible increase in the number of dermal fibroblasts.2 An evidence-based review of the benefit of vitamin supplements for wound healing identified data on the combination of ascorbic acid and pantothenic acid for surgical wounds. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur. Provitamin B5 or d-panthenol boosts the production of glutathione in your skin. Shalita AR, Smith JR, Parish LC, et al. Using topical formulations may help with acne as well. Pantothenic Acid in the Treatment of Acne Vulgaris Br J Dermatol 1977;97:681–4. I also came back due to a horrible internal discomfort that I thought might have been from parasites. Such high intake is potentially toxic and should only be done under the supervision of a physician. Because you only have to take around 900 mg or so of pantethine, there will be no adverse side effects. Pantothenic acid concentrations in human breast milk weakly correspond with maternal intake.2, 36, None well documented. Now that I am finished Breast feeding I started 5 grams again, but then I read about Pantethine and have been taking that for the last week. One small trial found 50 mg per day of vitamin B6 (pyridoxine) alleviated flare-ups of acne before the onset of their menstrual cycles.6. Jeffrey Dach MD Many of the steroidal hormones are made by the adrenal gland, so it is very logical that B5 deficiency can result in a syndromes called adrenal failure, or the inability to synthesis steroidal hormones such as Cortisol. • Chromium polynicotinate 200 µg or if you never used b5 but are having success with pantethine please share. Perhaps a combined approach supplementing with bioidentical hormones such as estradiol, progesterone, DHEA, Cortef, testosterone  as well as vitamin mineral supplementation with pantethine, and others would be the most logical way to help lupus patients get back their health. 8. The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician -- patient relationship. Good luck!!!! This product may be unsafe when used before surgery or other medical procedures. The face becomes less oily. This is only a brief summary of general information about this product. Low Adrenal Cortisol in Lupus We immediately began the Pantethine and L-Carnitine. For example, Quality of Life for Lupus patients seems to be ameliorated by DHEA administration, an adrenal hormone precursor. 2, (1997)). Since it's water soluble (not fat soluble) the excess will be excreted from your body. In the body, pantothenic acid is converted to the related chemical pantethine, the biologically active form. Tell your doctor if your condition persists or worsens. Carnitine transports long-chain acyl groups from fatty acids (Acyl group) into the mitochondrial matrix, so that they can be broken down through ß-oxidation to acetate to obtain usable energy via the citric acid cycle. PCOS (polycystic ovary syndrome) syndrome is associated with increased testosterone production and acne is common. Coenzyme-A is formed from adenosine triphosphate, cysteine and Pantothenic Acid. Below, we will make the case for a vitamin B5 deficiency as a cause for acne. Play around with dosage and see what works best for you, that's what I did. Systemic lupus erythematosus: a combined deficiency disease my skin is definitely alot drier now. Dermat., 18, 365-367. Here’s the science behind it, and a review by my sister on how it worked for her. It is well known that the Beta Oxidation of Fatty Acids depends on CoA. Increasing the amount of Acetyl CoA available speeds up the metabolism of fatty acids which are then used for energy production. After menopause when hormone production declines dramatically, there is a reduction in Lupus flares and the disease becomes quiescent. mg vitamin E. Some patients showed improvement of symptoms which the authors Within the first 3 weeks my skin started shining and smoothing out and I stopped seeing a doctor. Mild cases cleared in a couple of months and more severe cases took up to six months to clear. It's dangerous. adding that and zinc into my routine definitely helped me to control the problem. I've been waiting to post until I had something to say.....anyway, I've been takin B-5 for about 3wks (over 2 years ago I took about 5 Grams per day for a month or two and my acne cleared all up But then I started trying to concieve and didn't want to take any chances). Facebook, Links and References This information relates to an herbal, vitamin, mineral or other dietary supplement. One study found that zinc may be as effective as oral antibiotic therapy.3 It is recommended to take zinc with food to avoid getting an upset stomach. Furthermore, pantothenic acid is included at high dosage (at least 3-fold higher than all similar products that we are aware of) in an attempt to increase complex I activity and CoA levels, which in turn might help to facilitate a wide range of metabolic processes in the body. I know it's working because I've got to use Carmex on my lips and have a little bit dryer hands. How Effective Pantothenic Acid Acne Cure Is? multivitamin, biotin, ascorbic acid, calcium / vitamin d, Fish Oil. 5. Cholesterol is then used to make all steroidal hormones. Lupus, http://www.ncbi.nlm.nih.gov/pubmed/13985157 I was still pretty depressed, but at least my system was being cleansed. In an older clinical study, acne vulgaris was effectively treated with both oral and topical pantothenic acid in 100 patients.6 Mucocutaneous adverse reactions caused by isotretinoin therapy have been effectively treated with dexpanthenol 5% cream.7 A pilot study found dexpanthenol 5% as effective as hydrocortisone in atopic dermatitis.8. In accordance with Title 17 U.S.C. While this particular condition was considered to be a common, moderate case of acne… 9. It is the active ingredient in Vitamin B5. Accutane's most commonly reported  adverse side effect is depression which can lead to suicide. ][Article in Russian] TISHCHENKO LD. The authors also stated that “varying combinations and massive dosages of pantothenic acid derivatives and vitamin E preparations were given to 154 patients who had diseases other than lupus, http://archive.food.gov.uk/committees/evm/papers/evm0101.pdf If you use other drugs or over the counter products at the same time, the effects of Pantothenic Acid may change. Using this method, 12 SLE females were studied with promising results. An added advantage is a good cosmetic result with smaller pore size and smoother skin. 4. Acne is a Major Problem 2. http://www.ncbi.nlm.nih.gov/pubmed/13423891 somehow, it seemed as though my body was using the pantethine more readily than B5. Int J Dermatol 1995;34:434–7. Available for Android and iOS devices. Currently on minocycline, tazorac, 2.5% benzoyl peroxide. http://deficiencydiseases.com/SLE_full_text.pdf My oil slick of a face is almost at normal sebum levels already. This product has proven itself to be the total mind/body remedy we've all been looking for. I take 300 mg of Pantethine, 3 times a day, so 900mg total. Papers by Lit-Hung Leung, M.D. There is no credible scientific evidence to back this up. Considering the biochemical pathways involved, this would be possible with the addition of L-carnitine, which transports fatty acids across the mitochondrial membrane where they can be oxidized. There is a noticeable decrease in sebum secretion on the face usually 2-3 days after initiation of therapy. Increased stimulation of the skin and bacterial infections appear to play major roles in the development of acne. Treatment is replacement therapy with doses of pantothenic acid that is hundreds of times higher than that of the Dietary Reference Intake (DRI) and other vitamins. I wish I had seen the info on pantethine before starting b5 powder 10 days ago. Improves Lipid Profile. Pantothenic acid deficiency as the pathogenesis of acne vulgaris. But after several months, I came across a post on healthboards.com of a person who was using both pantethine and B5 and claimed that adding panthetine improved his skin more. The results of another study suggest that vitamin B5 (pantothenic acid) may also be useful in treating acne.4 However, participants in the study took 10 grams per day orally, which is an extremely large amount, and also used a 20% topical cream of vitamin B5 daily. Unlike Accutane which may have serious adverse side effects. I love the continuous results. Avoid use if hypersensitivity to pantothenic acid exists. A maintenance dose will not only act as a preventive measure against sporadic eruption, but the extra pantothenic acid will help to ease the relative deficiency state, and likely improve the general health of the patient. Acetyl CoA is the first step in the body's synthesis of Cholesterol. A case report of life-threatening eosinophilic pleuropericardial effusion with concomitant use of biotin 10 mg/day and pantothenic acid 300 mg/day exists.37, In high doses, pantothenic acid may inhibit the absorption of biotin produced by microflora in the large intestine; diarrhea may occur. 6. Pantothenic Acid in the present invention therefore reduces sebum production. This article describes the author’s personal experience with a moderate but chronic case of acne vulgaris and its many treatments over a 43 year period. This is done by increasing Coenzyme A (Co-A) which increases the metabolic breakdown of oils by normal activity of cell physiology. (From USD Biochemisty Lecture) In an older clinical study, acne vulgaris was effectively treated with both oral and topical pantothenic acid in 100 patients.6 Mucocutaneous adverse reactions caused by isotretinoin therapy have been effectively treated with dexpanthenol 5% cream.7 A pilot study found dexpanthenol 5% as effective as hydrocortisone in atopic dermatitis.8

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